Want to geek out on the science? Here are some of the clinical studies...

TND1128, a 5-deazaflavin derivative with auto-redox ability, facilitates polarization of mitochondrial membrane potential (ΔΨm) and on-demand ATP synthesis in mice brain slices.
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Effects of TND1128 (a 5-deazaflavin derivative), with self-redox ability, as a mitochondria activator on the mouse brain slice and its comparison with b-NMN.
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Studies designed to demonstrate improvement in cognitive functions including attention have deployed a large variety of approaches that can be categorized as pharmaceutical. (2023)
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Introduction of Apoptosis and Inhibition of Proliferation in Human Tumor Cells Treated with Extracts of Uncaria tomentosa. (Sheng, Pero, Amiri, and Bryngelsson: Anticancer Research 1998)
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Enhanced DNA repair, immune function and reduced toxicity of ac-11® (CMED-100®), a novel aqueous extract from Uncaria tomentosa. (Sheng, Bryngelsson and Pero: Journal of Ethnopharmacology 1999)
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Treatment of chemotherapy-induced leukopenia in a rat model with aqueous extract from Uncaria tomentosa. (Shen, Pero, Wagner: Phytomedicine 2000)
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DNA repair enhancement of aqueous extracts of Uncaria tomentosa in a human volunteer study. (Sheng, Homgren, Pero 2001)
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Serum Thiols as a Surrogate Estimate of DNA Repair Correlates to Mammalian Life Span. (Pero, Hoppe, Sheng: Journal of Anti-aging Medicine, 2000)
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ac-11® and NF-KB-inhibition…an additional pathway for why ac-11® improves our natural DNA repair processes. (In house data 2005 and summary 2012)
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Surrogate Indication of DNA Repair in Serum After Long Term Chiropractic Intervention-Retrospective Study. (Campbell, Kent, Bane, Amiri, Pero: Journal Vertebral Subluxation Res. 2005)
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Brunswick Labs, Certificate of Analysis, ORAC Value ac-11®
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Formulation and in vitro/in vivo evaluation of combining DNA repair and immune enhancing nutritional supplements. (Pero, Amiri, Sheng, Welther and Rich: Phytomedicine 2005)
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ac-11® claims substantiation document. (Zwiren 2010)
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BIO-EC: Protection and preventive activity of ac-11® after UV irradiation and anti-aging activity on human skin explants maintained in survival (2008)
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